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Pictured left to right: (Front) Pat O Flynn (Solvotrin Therapeutics), Mark Lotter (Nuance Pharma), (Back) Eva Su (Nuance Pharma), Libin Song (Enterprise Ireland), Tadhg O'Callaghan (Enterprise Ireland), Micheál Martin (Taoiseach), Ronan McClafferty (Solvotrin Therapeutics), Dr. Nicholas O'Brien (Ambassador of Ireland) and David Murphy (Consulate General of Ireland). SHANGHAI, January 7, 2026 - Solvotrin Therapeutics, a leading Irish healthcare developer, has officially announced an exclusive agreement with Nuance Pharma to distribute Active Iron in China. This partnership leverages Nuance Pharma’s robust commercial expertise in iron deficiency and women’s health to bring Ireland’s premier iron technology to a broader patient base.  The announcement was made during a Consulate General of Ireland Business Dinner at the Fairmont Peace Hotel, held on the occasion of the visit of An Taoiseach, Mr. Micheál Martin T.D. The event was hosted by the Consul General of Ireland, Mr. David Murphy, alongside Enterprise Ireland, IDA Ireland, and Bord Bia. Key attendees included Pat O’Flynn (CEO) and Ronan McClafferty (COO) of Solvotrin Therapeutics, and Mark Lotter (CEO) and Eva Su (VP, Commercial Excellence) of Nuance Pharma.  Pictured left to right: Pat O Flynn (Solvotrin Therapeutics), Mark Lotter (Nuance Pharma), Micheál Martin (Taoiseach),  A Breakthrough in Iron Supplementation Developed in collaboration with Trinity College Dublin, Active Iron’s patented SCFA Protein Iron technology marks a major breakthrough. This clinically proven product is renowned for superior tolerability and efficacy, solving the long-standing challenges of "iron intolerance" and "absorption bottlenecks." By delivering iron directly to the most active site of absorption via a unique protein-protected formula, it maximizes uptake while significantly minimizing side effects like nausea and constipation.  “We are pleased to announce this strategic partnership with Nuance,” said Pat O’Flynn, CEO of Solvotrin Therapeutics. “Nuance’s agile, innovation-led model makes them the ideal partner to introduce our trusted, clinically driven solutions to China. We also acknowledge the support of Enterprise Ireland in facilitating the initial engagement. Active Iron is now a leading brand across Europe and the United States, and we look forward to bringing a trusted, clinically driven solution to consumers in China.”  Mark G. Lotter, CEO of Nuance Pharma, added: “Partnering with Solvotrin represents an exciting opportunity to address a broader spectrum of iron-related health needs, particularly in women’s health. We look forward to making this standout product accessible to patients across China.” 

Many people feel the positive effects of taking an iron supplement after three weeks, but it may take up to 12 weeks to feel a noticeable increase in iron and energy levels¹.  Iron needs differ from person to person; as such, everyone feels the effects of iron supplementation on their own timelines. Each person will experience different levels of sensitivity, side effects, and positive improvements from iron supplements.  Here we will break down some of the most common questions about restoring iron levels, so you can be confident that you are getting the most from your iron supplement.   How Long Will My Iron Supplement Take To Work & What Does That Mean?  If you were to Google “How long does it take for iron supplements to work?” the current AI-generated answer suggests one to four weeks. However, it’s impossible to predict exactly when you’ll feel the effects. Several factors influence iron absorption and the rate at which your body responds, including the time of day you take iron, your overall iron requirements, and your individual metabolism. It’s also important to distinguish between how long it takes for iron to “work” (typically when you notice improved energy) and how long it takes for your body to absorb iron.  How Long Does It Take Active Iron To Work?   Active Iron is clinically proven to increase iron and energy levels within six weeks¹, though many people notice improvements after about three weeks. The timing depends on how efficiently your body absorbs iron. Active Iron is formulated for optimal absorption², helping your body gradually build iron stores so you can start feeling the benefits within a few weeks, depending on individual differences. Active Iron is also clinically proven to be gentle and non-constipating and can be taken on an empty stomach. How Long Does It Take For Your Body To Absorb Iron?  The time it takes to restore iron in your body depends on several factors:  Reason for low iron levels: Low iron due to poor diet, heavy periods, or blood loss can affect how quickly your levels recover.  How low your levels are: The further below normal your iron levels are, the longer it takes to replenish them.  For example, if you experience regular or heavy periods, it may take longer to rebuild iron stores because you continue to lose iron. On the other hand, if dietary intake is low but supplementation is consistent, iron levels can improve more steadily, especially with supplements designed for good absorption.  What To Consider When Taking Iron Supplements  Maintaining an iron-rich diet can be challenging, especially if you follow a restricted diet, e.g. vegetarian.   Foods that can reduce iron absorption  Certain foods and nutrients naturally inhibit iron absorption, making it harder to reach optimal iron levels. These include:  Phytic acid (commonly found in grains and legumes)  Tannins  Polyphenols (found in tea, coffee and matcha)  Milk  Caffeine  Some proteins present in soybeans  Given that many people start their day with a cup of coffee or a bowl of milk and cereal, it’s easy to see why getting enough iron can be a challenge.  Foods That Can Increase Iron Absorption  Some foods can increase your body’s ability to absorb iron and are often recommended alongside iron supplements. These include:  Citrus fruits and citric acid – lemons, oranges, orange juice  Vitamin C-rich foods  Foods containing vitamin A and beta-carotene  Incorporating these foods into your diet can help improve iron absorption and support your overall iron levels.  If you feel tired and fatigued all the time or suspect having low iron levels, the best step is to consult your GP. They can perform a blood test to identify whether low iron is contributing to your wellbeing and determine the underlying cause. When you speak to your GP, we would recommend asking them to check both your ferritin and haemoglobin levels, as these give a fuller picture of your iron stores and overall iron status. Based on the results, your GP can advise if an iron supplement would be suitable for you.  Conclusion: How Long do Iron Supplements take to Work?  Iron supplementation can take several weeks to show noticeable effects, with timing varying based on individual needs, absorption efficiency, and dietary factors. Combining supplements with an iron-friendly diet can support faster recovery. Active Iron is a good choice for those looking for a supplement, as it is clinically proven to increase iron and energy levels¹ while being gentle on the stomach.   Iron Absorption FAQ’s  How quickly do iron supplements work?  Many people feel the positive effects of taking an iron supplement after three weeks, but it may take up to 12 weeks to feel a noticeable increase in iron and energy levels.  How long should I take iron supplements for?  Iron supplements should be taken for at least 6 months and up to 12 months. The best way to ensure adequate absorption is to take them on an empty stomach or allow 2 to 3 hours between meals, as certain foods, drinks, and medicines may inhibit iron absorption.  How long does it take to raise iron levels with food?  Raising iron through diet alone can be difficult, especially for those with increased needs, e.g. restricted diets, pregnancy, and heavier periods. Dietary iron comes in two forms: Haem and Non-Haem. Haem iron, found in red meat, offal, and poultry, is absorbed more easily and is best for boosting iron levels. Non-Haem iron sources include fortified cereals and leafy greens like broccoli and cabbage.   How do you know if iron tablets are working?  Everybody responds to iron supplements differently, but most people can expect to see an improvement in their energy levels, an improvement in their ability to concentrate and a healthier immune system.   These signs may not be very pronounced, so it’s still important to review how much iron you consume through your diet and how well your iron pills are being absorbed.  If you have any concerns that your iron pills are not working, you should consult your GP.   Sources:   Ledwidge, M. et al. PRECISION Study. Int J Clin Pharm (2023) https://doi.org/10.1007/s11096-023-01640-7   Wang et al. 2017, Acta Haematologica, 

Among the body’s essential minerals, iron and calcium stand out as two of the most important. Iron’s main role is to help transport oxygen around the body. It’s also important for brain function¹ and a healthy immune system. Calcium is vital for maintaining strong bones and teeth², and it also plays an important role in normal blood clotting. For optimal health and well-being, calcium and iron are essential components of a balanced diet.  Calcium &Iron Absorption  Calcium can affect iron absorption, especially non-haem iron found in plant-based foods. In some studies, ³⁴ calcium has been shown to bind to iron in the gut, making it more difficult for the body to absorb. This effect is stronger with larger amounts of calcium, such as from supplements or dairy products. Calcium can also slightly reduce the absorption of haem iron from animal sources, but the effect is generally smaller. Over the long term, and in the context of a normal diet, calcium’s impact on iron absorption is usually minor.  Can you take Calcium & Iron Together?  As part of a balanced diet, it’s perfectly safe to consume calcium and iron together. However, to maximise iron absorption, it can help to consume high-calcium foods or supplements a few hours apart from iron-rich meals. In an ideal world, we would get all the calcium and iron we need from our diet. However, some people struggle to meet their needs through food alone, so they take calcium and iron supplements to help maintain healthy levels of both nutrients.  When it comes to taking calcium and iron supplements, it’s best not to take them at the same time. Calcium can have a short-term effect on iron absorption. To avoid this, take your iron supplement separately from your calcium supplement. It is recommended to allow 3-4 hours between taking your iron and calcium supplements. Generally, the best time to take your iron supplement is between meals or 30-60 minutes before eating. This includes tea, coffee, and dairy products.  Foods Rich In Iron & Calcium  Here’s a list of the best foods to eat if you want to increase calcium and iron in your diet.  Food Group Examples Nutrient Focus  Meat, Fish & Eggs  Red meat, canned tuna, sardines, eggs  High in both iron and calcium (especially sardines with bones)  Beans & Lentils  Lentils, chickpeas, kidney beans, black beans  High in iron; moderate in calcium  Vegetables  Kale, spinach, broccoli, bok choy  High in calcium; leafy greens also contain iron  Nuts & Seeds  Pumpkin seeds, almonds, walnuts, sesame seeds  Moderate to high in both iron and calcium  Fruits  Dried fruits (raisins, apricots, prunes)  High in iron  Oranges, blackcurrants, blackberries   High in calcium    Can I Take Active Iron with a Calcium Supplement?   Yes, you can take Active Iron and a calcium supplement, but it’s best to take them at different times. Try to leave about 3–4 hours between each to support optimal absorption. Taking iron on an empty stomach can also help your body absorb it more efficiently. Active Iron’s ground-breaking formula is gentle on the stomach and easy to absorb³. Active Iron’s clinically proven formula provides a higher rate of absorption of iron than other oral irons on the market. Active Iron is so gentle that you can take it on an empty stomach.  Conclusion: Iron & Calcium   Iron and calcium are essential minerals, vital to our health and wellbeing. With today’s busy lifestyles, getting enough from the food we eat alone can be a challenge. For many people, iron and calcium supplements offer the perfect solution. And the good news is, it is possible to take calcium and iron together. Just make sure you take them at different times of the day to get the best results.  Our expert team is here to help. If you have any concerns about taking Active Iron with your calcium supplement, please email us at info@activeiron.com  References: ¹Iron contributes to normal cognitive function  ²Calcium is needed for the maintenance of normal bones and teeth  ³The Journal of Nutrition doi: 10.1093/jn/nxaa437  ⁴The American Journal of Clinical Nutrition, Volume 53, Issue 1, January 1991, Pages 112–119, https://doi.org/10.1093/ajcn/53.1.112  ⁵Wang et al. 2017, Acta Haematologica, 138: 223-232   

This article is for you if: You want to learn the best time to take vitamins You want to learn more about each vitamin inside your average multivitamin Should You Take Vitamins in the Morning or at Night? To answer the first question right off the bat, the best time to take vitamins and supplements will largely depend on what vitamins you are taking. Not all vitamins are created equal. Moreover, when most people say vitamins, they mean micronutrients that fall into both the vitamin and mineral categories. Some of them should be taken in the morning with a meal to maximise absorption. Others are best taken in the evening before bed. Let’s talk about vitamins and minerals for each of the main groups you can find in the store: Multivitamins Vitamin B Vitamin D Vitamin C Vitamin E Folic acid  Magnesium Omega-3 Fatty Acid Zinc Getting adequate levels of vitamin C, D, and iron is essential for a healthy immune system. Your immune system is your body’s natural defence against illness. If you are unable to meet your nutritional needs solely through food, supplementing with multivitamins in conjunction with iron supplementation is an effective way to support your immune system. However, Food supplements are not a substitute of a healthy and balanced diet and lifestyle CTA HERE Best Time to Take Multivitamins You should take your multivitamins in the morning with a meal to maximise absorption. However, if this causes any stomach issues, try taking them before bed. Remember, consistency is key here! People who can benefit the most from taking multivitamins are: Adults Vegans & Vegetarians When is the Best Time of Day to Take Prenatal Vitamins? Pregnant and breastfeeding women may benefit from taking prenatal vitamins because of their increased requirement for essential nutrients. However, it is advised that pregnant women or those on medication check with a healthcare professional before taking vitamin or mineral supplements.  As with traditional multivitamins, prenatal vitamins are best taken in the morning, with a meal, and consistently. According to the Cleveland Clinic, the best time to take vitamins D, C, and B, are as follows: Best Time to Take Vitamin D: Vitamin D is fat-soluble, meaning it doesn’t dissolve in water, so you should pair it with high-fat foods to ensure proper absorption. It is essential to incorporate Vitamin D into your routine, ideally alongside breakfast or as part of your bedtime snack (as long as it doesn’t interfere with your sleep). Vitamin D is best taken in the morning, lunchtime, or evening, when you have high-fat foods such as a glass of whole-fat milk, avocado, olive oil, or flax. Best Time to Take Vitamin CVitamin C is a water-soluble vitamin, meaning it is best taken with water. You should take vitamin C in the morning, on an empty stomach.  Best Time to Take B Vitamins The best time to take B vitamins is after you wake up, preferably with a meal to maximise absorption¹.  What role does each B vitamin play?Vitamin B-1 is known as Thiamine. Thiamine contributes to normal energy-yielding metabolism, normal functioning of the nervous system, psychological function, and the normal function of the heart. Good sources of Vitamin B-1 include: Pork Fish (like salmon and tuna) Legumes (like beans and lentils) Nuts (like sunflower seeds and pecans) Whole grains (like brown rice and oatmeal), fortified cereals, and eggs. Vitamin B-3 is also called Niacin. Can be incorporated into your diet through peanuts, fish, brown rice, and whole grains. Vitamin B-6 contributes to normal protein and glycogen metabolism. It is vital for the efficient breakdown of food - particularly carbohydrates - into smaller units the body can utilise. Additionally, Vitamin B6 helps regulate hormonal activity. Good sources include bananas, tuna, chickpeas, and pistachios. Vitamin B-9, also known as Folate, contributes to normal blood formation. It’s one of the building blocks of DNA and RNA. Good sources include avocados, leafy greens, broccoli, green peas, and more. Vitamin B-12 is only found in animal products. Vitamin B-12 is crucial to the normal functioning of the nervous system. It helps to create and regulate RNA, and it’s also involved in the formation of red blood cells. The best time to take vitamin B-12 is in the morning, similar to all B vitamins. Best Time to Take Omega-3 Fatty Acids (Fish Oils)Omega-3 fatty acids are “healthy fats” and can be taken at any time of the day. To improve the absorption of omega-3, you should take it with a meal that includes fats² such as avocado, flax, or whole-fat milk. This can help reduce the side effects as well as enhance the effectiveness of the supplement. Omega-3 (EPA & DHA), found in fish oil and seeds like flaxseed, is a vital nutrient for your body. DHA contributes to normal brain and eye function, while both EPA and DHA contribute to normal heart function. Best Time to Take Folic Acid Folic acid is the man-made version of Vitamin B9 (Vitamin Folate). Folate contributes to maternal tissue growth during pregnancy and normal blood formation. Supplemental folic acid intake increases maternal folate status. Low maternal folate status is a risk factor in the development of neural tube defects in the developing foetus. This beneficial effect is obtained with a supplemental folic acid daily intake of 400μg for at least one month before and up to three months after conception. You can take folic acid at any time of the day. Folic acid is a water-soluble supplement, meaning it is best to take it with water. Best Time to Take Magnesium Most healthcare professionals would recommend taking magnesium with a meal due to the possible gastrointestinal side effects if a high dose is taken, which could cause diarrhoea on an empty stomach³. As a result, you can split the dose into two (breakfast and dinner). Magnesium is an essential nutrient that affects many functions in the body. Magnesium contributes to electrolyte balance, normal protein synthesis, psychological function, the maintenance of normal bones and teeth, normal muscle and nervous system function and reduction of tiredness and fatigue. Magnesium is such an important mineral that, even if you’re not taking it at the “perfect time”, just the fact that you’re taking it consistently is more than enough. Best Time to Take Vitamin E Vitamin E contributes to the protection of cells from oxidative stress. Vitamin E is a fat-soluble vitamin that requires natural fat in our meals for absorption and works best when taken with a meal containing fat. Best Time to Take Zinc Zinc contributes to the normal function of the immune system. It is best to take zinc one or two hours before meals, with a glass of water. You can take zinc at any time of day. Best Time to Take Water-Soluble vs Fat-Soluble Vitamins In this guide, we have already touched upon several fat-soluble and water-soluble vitamins individually. For example, Vitamin D is a fat-soluble vitamin, meaning it is best taken with high-fat foods. As a result, the best time of day to take fat-soluble vitamins should be based on your eating pattern and when this type of vitamin will be most easily absorbed. This can mean taking them after your breakfast or your last meal of the day. On the other hand, water-soluble vitamins are best taken on an empty stomach. This can mean taking them as soon as you wake up or more than two hours after eating. An example of water-soluble vitamins includes Vitamin C, which also occurs naturally in several popular products, including orange juice. Can I take my Vitamins at Night? You can choose to take any vitamin at night that does not interrupt your sleep or will not affect the absorption of the vitamin. As a result, you can take the following vitamins at night: Iron Vitamin D Vitamin C Vitamin E Magnesium When to Take Vitamins Chart Our easy-to-follow table has combined all of the content above to show the best time of day to take each type of vitamin supplement.  Type of Vitamin Best Time of Day to Take Multivitamins Morning - with a meal. Prenatal Vitamins Morning - with a meal. Vitamin B  Morning - with a meal. Vitamin D  Any time - with a meal containing fat, like avocado or whole-fat milk. Vitamin C Morning - empty stomach, with water. Folic Acid Any time - with water. Iron Any time - on an empty stomach, or 1-2 hours between meals. Magnesium Any time - with a meal. Omega-3 Fatty Acids Any time - with a meal containing fat, like avocado or whole-fat milk. Vitamin E Any time - with a meal containing fat, like avocado or whole-fat milk. Zinc Any time - 1-2 hours between meals with water.   Conclusion Some vitamins and minerals have golden windows that reduce irritation or boost effectiveness, so check with your doctor for interactions with medications. The takeaway here is consistency is key - make them part of your morning or bedtime routine to build the habit and maximise benefits. References: ¹Cleveland Clinic, 2021 https://health.clevelandclinic.org/the-best-time-to-take-vitamins ²Veronica Zambon, 2025 https://www.medicalnewstoday.com/articles/when-to-take-fish-oil ³Rachael Ajmera and Sandra Silva, 2025 https://www.healthline.com/nutrition/best-time-to-take-magnesium

Tired of the gastrointestinal side effects associated with most iron supplements? In this article, we will explore ways to increase your iron levels, without the nasty side effects!

Iron-rich cereals offer a simple, delicious way to support your iron levels! In this article, we will explore cereals that have a high iron content. Pair your bowl with vitamin C-rich fruits like strawberries or oranges to maximise absorption, and you’ve got a powerhouse breakfast that fuels both your body and mind.

At Active Iron, we aim to provide the best possible support for your health, especially during pregnancy and beyond into the postnatal period. With this in mind, we have an important update regarding our Active Iron Pregnancy range. We have decided to discontinue our Active Iron Pregnancy 17mg product and Active Iron Pregnancy Plus and have launched a new and improved Active Iron Pregnancy.  During pregnancy, the amount of blood in your body increases by up to 50%. This increases the requirement for iron as it is needed to make haemoglobin, which carries oxygen around your body. We are recommending Active Iron Advance 25mg for those looking for an iron-only product in pregnancy, and the new Active Iron Pregnancy for those looking for a complete nutritional solution for mum & baby. Why Active Iron Advance? Active Iron Advance offers the same great formula in a higher 25mg dose to fulfil the increased iron requirements during pregnancy. It is specially formulated to help avoid side effects such as nausea and constipation, making it kind on the stomach while also being strong enough to increase iron levels. Active Iron Advance is clinically proven to increase iron levels by 94% in 6 weeks*, making it a comfortable and more effective iron supplement for expectant mothers. Why Active Iron Pregnancy? Active Iron Pregnancy provides the essential nutrients mum and baby need throughout each trimester. During pregnancy, your blood volume expands by up to 50% and nutritional requirements increase to support the healthy development of your growing baby. This boosts your requirement for iron and other key nutrients. Active Iron Pregnancy contains non-constipating Active Iron plus a complete time-release multivitamin providing all the key nutrients mum and baby need throughout pregnancy, including: Iron and B Vitamins (B2, B5, B6, B12, and biotin) to support energy production and help fight tiredness and fatigue Iron to support blood building and oxygen transport Folic acid as highly absorbable L-Methylfolate to help support foetal development** Vitamin D, vitamin C, zinc, and iron to support immune function Vitamin B5 to support mental performance and iron, iodine, and zinc to support cognitive function Calcium, magnesium, vitamin D, and vitamin K to support bone and muscle health Vitamin B6 to help regulate hormonal activity Vitamin E, copper, and selenium to help protect cells from oxidation. New Clinical Study To continue supporting our claims on Active Iron, in 2024, we initiated a brand-new clinical study with pregnant women. This study, conducted in partnership with Ulster University, will focus on the impact of iron supplementation during pregnancy, and the benefits of early intervention of iron supplementation on outcomes for mum & baby. *Ledwidge, M. et al. PRECISION Study. Int J Clin Pharm (2023) https://doi.org/10.1007/s11096-023-01640-7

Active Iron Partners with Clue to Help Women Combat Menstrual Fatigue and Manage Reproductive Health

Solvotrin Therapeutics, a leading Irish healthcare development company, is delighted to announce the signing of a long-term licensing agreement with Norwell Consumer Healthcare for the Active Iron brand in Canada.

Solvotrin Therapeutics, a leading Irish healthcare development company, is pleased to announce an exclusive agreement with Ortho Molecular Products for the distribution of Active Iron in the U.S. practitioner channel.